Structural Validation Funnel
HIGH-THROUGHPUT PROTEIN SCREENING PIPELINE
Pause
Next Candidate
Reset
10k
PASS
FOLDED
TIER 1
Kd > 100nM
CLASH
pLDDT<70
01 // INPUT POOL
02 // AFFINITY LAYER
03 // STRUCTURAL LAYER
04 // CONFIDENCE TIERS
05 // SYNTHESIS
SEQUENCE POOL
KD SCREENING
LATTICE GATE
pLDDT METRIC
LEAD SYNTHESIS
NON-BINDERS
MISFOLDED DROP
LOW CONFIDENCE
Active Candidate Profile
Candidate Identifier
#1092-ALPHA
Current Pipeline Stage
01 // Input Pool
Affinity (Kd)
--
Lattice Geometry Fit
--
Confidence Score (pLDDT)
--
TIER --
Pipeline Disposition
QUEUED